I was thinking about the ability we now have to eventually craft our own personal weapon through the Pits, and it inspired me to chase the train of thought.
What if we add some quests for shop keepers in various cities, that would provide characters an opportunity to gather other personalized quest items?
Perhaps the blacksmith in the Marak has a craving for a slice of pizza, and if you deliver it he will craft you your very own chest guard or shield.
Maybe the staff salesman in Aeria has a fondness for red grapes, if you deliver some he will repair his broken staff of wonder.
We could even further customize the attributes of crafted quest items by weight, bonuses, ect. based on exactly what city the shop keep is in.
So that items crafted in the elven city for instance would have a greater likelihood of being +hp, where items crafted in Marak may be -affl.
Just a thought, I figured I would share.
Edit: While I mention only one item, obviously for a quest item you would get sent on several retrieval missions before the shop keep delivered on his promise.